منابع مشابه
Domain–domain interactions in ion channels
347 C o m m e n t a r y Ion channels are, with a few exceptions, multi-subunit complexes made of interacting functional domains (Hille, 2001). Combining different functionalities yields ion channels with complexity, allowing them to operate like a biological micro-machine. This general design permits the selective regulation of channel behaviors, such as the single-channel conductance or the ac...
متن کاملO 13: Ion Channels in Autoimmune Neurodegeneration
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
متن کاملInteractions of polyamines with ion channels.
Endogenous polyamines, in particular spermine, have been found to cause block and modulation of a number of types of ion channel. Intracellular spermine is responsible for intrinsic gating and rectification of strong inward rectifier K+ channels by directly plugging the ion channel pore. These K+ channels control the resting membrane potential in both excitable and non-excitable cells, and cont...
متن کاملo 13: ion channels in autoimmune neurodegeneration
multiple sclerosis (ms) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. ionic conductances regulate t cell activation as well as neuronal function and thus have been found to play a crucial role in ms pathogenesis. since present therapeutical approaches are only parti...
متن کاملMetal interactions with voltage- and receptor-activated ion channels.
Effects of Pb and several other metal ions on various distinct types of voltage-, receptor- and Ca-activated ion channels have been investigated in cultured N1E-115 mouse neuroblastoma cells. Experiments were performed using the whole-cell voltage clamp and single-channel patch clamp techniques. External superfusion of nanomolar to submillimolar concentrations of Pb causes multiple effects on i...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2013
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.201311090